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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.75 mg or more at intervals up to 2 months (P < .02). In clinical trials with several types of corticosteroids, there have been a number of reports. One of the more important studies was that of Raffin et al, where a double-blind, placebo-controlled, multicenter study compared the use of prednisolone with metoprolol and domperidone for acute inflammation in patients with moderate or severe exacerbations of rheumatoid arthritis.20 Based on a randomized, double-blind, controlled trial, the use of prednisolone at 0.5 mg/kg was associated with statistically significant reductions in the number and severity of inflammatory lesions compared to placebo, which was statistically significant at the 1-week interval and at the 3-week interval. The authors concluded that at doses higher than 0.5 mg/kg, prednisolone could be a useful clinical alternative to metoprolol or domperidone in the treatment of severe inflammation of arthritis. Another study by Vangiorelli et al20 showed favorable clinical and radiographic outcomes in a study of patients treated with prednisolone, but this did not show differences between the groups. Other studies have shown good results in the treatment of moderate to severe inflammation in patients with or without arthritis in the use of prednisolone. For example, at 0.5 mg/kg of prednisolone, the frequency of neutropenia, the presence of neutrophils within and around the lesion, and the number of neutrophils in bone marrow were significantly reduced compared to the placebo group. The patients also had a decrease in the number of neutrophils, with less neutrophils being associated with more severe symptoms in patients receiving prednisolone. The authors concluded that this study demonstrates the efficacy of prednisolone in patients with severe inflammation of rheumatoid arthritis. In a double-blind trial by Pérez-Alegria et al,21 the use of prednisolone is associated with a significant reduction in the number of patients with systemic lupus erythematosus (SLE). Although SLE is a serious disease characterized by a substantial number of patients with a high rate of treatment-related adverse events, a review of the studies to date indicated that, for the time being, the use of prednisolone in the treatment of SLE is not superior to that of other oral anti-inflammatory agents. In addition to Similar articles:
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